PPARG and Atrophy: Furthermore, these beneficial changes such as the prevention of renal atrophy and fibrosis of telmisartan were connected with a diminishing in the expression of TGFβ1 and other proinflammatory and profibrotic cytokine genes via the PPARγ/HGF activation (Kusunoki et al., 2012), independent of Ang II type 1 receptor blockade.