The immunosuppressive entities harbored in the exosomes e.g., PD-L1, VEGF, MICA, ULBP-1, HLA variants, Fas L, TRAIL, IL-10 etc. target similar immune cell subsets like Th1, Tregs, DCs and NK cells thus, promoting the anti-inflammatory niche required for the fetus and cancer development post its implantation and establishment respectively (Figure 6B). The gene discussed is CD274; the disease is cancer.