CD4 and gestational diabetes: Decreased Treg numbers are associated with GDM prognosis, as shown in multiple studies where subsets of suppressive Tregs, CD4+CD127LOW+/CD25 + Tregs and CD45RA Tregs were evaluated during GDM pregnancies and represented a decline of anti-inflammatory function of Tregs as early as in the first trimester of GDM pregnancy (Schober et al., 2014).