HP and gestational diabetes: A hemoglobin-haptoglobin scavenger receptor CD163 (sCD163) is scraped out of MØ as an activation marker of these cells and this shedding is significantly increased in GDM women thus, the increased circulatory levels of CD163 from the placenta as well as from adipose tissue are reflective of GDM (Figure 2C) (Dige et al., 2014).