In recent years, accumulating evidence has indicated that genetic factors, particularly transforming growth factor (TGF-β) signaling, play a key role in the development of aortic aneurysms, in addition to regulating many aspects of physiological homeostasis in embryonic and adult tissues (Lindsay and Dietz, 2014; Isselbacher et al., 2016; Tzavlaki and Moustakas, 2020). The gene discussed is TGFB1; the disease is aortic aneurysm.