Lentivirus knockdown of SMAD7 prevented AngII-induced Smad3+/−Mir-21−/− mouse TAAD formation (Huang et al., 2018), and VSMC-specific miRNA-214 knockout inhibits AngII-induced hypertension through up-regulation of SMAD7 (Li et al., 2021b). Here, AGT is linked to hypertensive disorder.