Angiotensin II-induced disease in the abdominal aorta is exacerbated by systemic TGF-β blockade, and thoracic aortic disease is exacerbated by SMC-specific loss of TGBR2, which suggest that TGF-β signaling prevents abdominal and thoracic aneurysmal disease by different mechanisms (Angelov et al., 2017). This evidence concerns the gene TGFB1 and Vascular dilatation.