Carolyn and Douglas have previously reported some cases of myocarditis induced by PD-1/PD-L1 inhibitor treatment, with strong evidence of lymphocytic infiltration when the PD-1\PD-L1 axis was cut (Johnson et al., 2016; Glass and Mitchell, 2017), which was consistent with the histological examination in myocarditis cases (Tarrio et al., 2012; Heinzerling et al., 2016; Chen et al., 2018; Ganatra and Neilan, 2018; Mir et al., 2018; Yamaguchi et al., 2018; Martin Huertas et al., 2019). This evidence concerns the gene CD274 and myocarditis.