Furthermore, inhibition of PI3K activity with LY294002 or antagonism of TRPV1 with capsazepine, reversed the protective effect of OEA against DIC in cardiomyocytes, as demonstrated by myocardial fibrosis (Figures 6A,B), cardiac tissue damage (Figures 6C,D) and increased number of apoptotic cells (Figure 7). This evidence concerns the gene TRPV1 and Myocardial fibrosis.