In addition, increased Eotaxin, IL10, IP10, and MCP1 are found in anti-MDA5 patients with interstitial lung disease (Asakawa et al., 2020); In patients with rapidly progressive interstitial lung disease (RP-ILD), IFNγ, IL1β and IL12 levels are considerably elevated (Ishikawa et al., 2018). Here, IFIH1 is linked to interstitial lung disease.