Anti-ARS positive and anti-MDA5 positive IIMs are often associated with interstitial lung disease (ILD) (Satoh et al., 2017; Allenbach et al., 2020), anti-TIF1-γ positive IIMs are associated with malignancy (Hida et al., 2016), and anti-SRP positive IIMs are associated with severe muscle weakness (Dalakas, 2016). This evidence concerns the gene IFIH1 and interstitial lung disease.