Foxp3+ Treg cells limited the hyper-inflammatory response during early phase of sepsis,9 and induced immune-suppression in the later stages of sepsis.10 Under inflammatory conditions, activated immune cells turn metabolic reprogramming.11–14 Metabolic reconfiguration influences both the effector phase of inflammation and the resolution of inflammation by modulating immune cell fate and function. The gene discussed is FOXP3; the disease is Sepsis.