From the perspective of the oncologically oriented radiochemist/radiopharmacologist, COX-2 is a highly promising drugable target because (i) under physiological conditions it is nearly absent in tissues except kidneys, heart, and brain, (ii) its expression is inducible and COX-2 is overexpressed at inflammatory sites and in (inflamed) tumor tissue, and (iii) the availability of clinically approved drugs would allow the clinician to intervene in a personalized manner in, e.g., radioresistant tumors with high COX-2 expression. Here, PTGS2 is linked to neoplasm.