PLAU and cancer: In PCa, hypermethylation of RARβ, cyclin D2 (CCND2), GSTP1, MGMT (Tang et al., 2013; Dumache et al., 2014; Litovkin et al., 2015; Gurioli et al., 2016) and hypomethylation of MYC, uPA, PLAU, S100P (Wang et al., 2007; Gurel et al., 2008; Hagelgans et al., 2013), may promote cancer cell proliferation, progression and metastasis and lead to poor clinical outcomes.