The researchers implicated that CDKN2B-AS1 could putatively act as a sponge of miR-98-5p and increase the levels of its target protein notch homolog 2 (NOTCH2), which was an important regulator of renal fibrosis (Huang et al., 2018; Xiao et al., 2021). This evidence concerns the gene NOTCH2 and renal fibrosis.