Excessive proliferation of MCs was a significant pathological feature of various glomerular diseases, including lupus nephritis, IgA nephropathy, and DKD (Suzuki et al., 2011; Lei et al., 2019; Gao et al., 2020), with an increased synthesis of extracellular matrix protein such as col-IV, collagen-V (col-V), laminin (LN), and FN (Mason and Wahab, 2003), eventually promoting glomerular fibrosis of DKD (Chen et al., 2003). The gene discussed is LAMB2; the disease is diabetic kidney disease.