Evidence showed that lncRNA taurine-upregulated gene 1 (TUG1) could regulate the expression of peroxisome proliferator-activated receptor-γ coactivator-1 alpha (PGC-1α) in kidney biopsy tissue of DN patients and HG-cultured podocytes (Shen et al., 2019). This evidence concerns the gene TUG1 and liver dysplastic nodule.