The most significantly up-regulated genes were DPP6, ADGRB1, SCGB1A1, S100A7, and RPS28, and the most significantly down-regulated genes were BRCA1, NBR2, ZIC1, CDH18, and LIN28B. Based on these results, we can see that BRCA1-deficient ovarian cancer cells expressed lower levels of BRCA1 mRNA as expected. The gene discussed is S100A7; the disease is ovarian cancer.