Knock-out of Il22bp which resulted in increased IL-22/IL-22BP ratio accelerated tumorigenesis in the dextran sulfate sodium (DSS)-azoxymethane (AOM) colitis-associated CRC mouse model as well as in Apcmin/+ mice that develop intestinal adenomas (Huber et al., 2012). Here, IL22RA2 is linked to colorectal carcinoma.