Tengesdal et al. have demonstrated this using the B16-F10 melanoma model and further showed that Nlrp3 inhibition with dapansutrile (OLT1177) abrogated the expression of immunosuppressives genes in PMN-MDSC and enhanced anti-tumor immunity in vivo (Tengesdal et al., 2021b). This evidence concerns the gene NLRP3 and melanoma.