IL18 and metabolic dysfunction-associated steatotic liver disease: For instance, the NLRP1-IL-18 pathway was shown to promote the generation of mature MDSCs in multiple myeloma (Nakamura et al., 2018), and the Nlrc4 inflammasome in controlling CRC metastasis to the liver in non-alcoholic fatty liver disease (NAFLD) (Ohashi et al., 2019).