This was demonstrated using the diethylnitrosamine (DEN) mouse model of hepatocellular carcinoma (HCC), in which the mitophagy effector FUNDC1 was specifically deleted in hepatocytes leading to aberrant activation of the Nlrp3 inflammasome and IL-1β-driven hepatocyte hyperproliferation (Wenhui Li et al., 2019). This evidence concerns the gene NLRP3 and hepatocellular carcinoma.