BAX and differentiated thyroid carcinoma: Feng et al. (2019) demonstrated that NIBAN1 seems to play an important role in down-regulation of apoptosis due to its interaction with the MDM2/p53/Bcl2/Bax pathway. NIBAN1 overexpression induced an increase in MDM2 and Bc12 while decreasing p53 and Bax, responsible for cell death. It had been demonstrated that NIBAN1 silencing leads to increased apoptotic levels in follicular and papillary thyroid carcinomas cell lines (Carvalheira et al., 2015). These findings suggest that NIBAN1 may indeed be involved in apoptosis.