These data suggest that NIBAN1 may play a dual role in the autophagy regulation: 1) It can increase baseline autophagy in normal thyroid cells in response to nutrient and growth factors depletion, and 2) can inhibit autophagy in thyroid carcinomas in the presence of activating mutations in oncogenes (Nozima et al., 2019). This evidence concerns the gene NIBAN1 and thyroid gland carcinoma.