Zhang N. et al. (2019) demonstrated that NIBAN1 seems to up-regulate MMP2 and Cyclin D1, inducing cell proliferation and invasion, in the development and progression of non-small cell lung cancer. These findings have been corroborated in both colon cancer and thyroid carcinoma cell lines, whose results showed that decreased NIBAN1 expression inhibits cell proliferation and migration (Carvalheira et al., 2015; Yuki et al., 2015). The gene discussed is NIBAN1; the disease is malignant colon neoplasm.