Aside from being a receptor for SARS-CoV-2, ACE2 plays important role in different tissues in controlling blood pressure (Wysocki et al., 2010; Wang et al., 2020; Wysocki et al., 2021) or preventing heart failure and kidney injury (Wong et al., 2007; Batlle et al., 2012; Mizuiri and Ohashi, 2015). Here, ACE2 is linked to heart failure.