BUB1B and childhood malignant neoplasm: In terms of BUB1B mutation, Hanks et al. suggested that the genetic progression of BUB1B in rhabdomyosarcoma from mosaic variegated aneuploidy (MVA) and non-MVA cases may be similar, but that somatic BUB1B mutations were unlikely to be common in sporadic childhood cancers known to be associated with MVA 26.