In addition, LASS2 has been demonstrated to promote tumor cell apoptosis via ceramide 24, 25, an effect that can be reduced when ceramide is converted into survival-promoting sphingosine 1-phosphate (S1P) by sphingosine kinase 1 (SPHK1) in glioblastoma 26, 27. This evidence concerns the gene CERS2 and glioblastoma.