In the training set, the multivariate analysis before PSM showed that the HB-CEA (HB-CEA=1, HR: 1.840, 95% CI: 1.134-2.985, p=0.013; HB-CEA=2, HR: 3.255, 95% CI: 1.927-5.500, p<0.001), pathological TNM stage (pTNM) (HR: 1.800, 95% CI: 1.125-2.881, p=0.014), and lymph node metastasis (HR: 2.134, 95% CI: 1.217-3.741, p=0.008) were predictors of the clinical outcome (Table 4). The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.