SAPCD2 and colorectal carcinoma: The same group found that the effect of SAPCD2 knockdown on cell cycle redistribution differed between two different CRC cell lines, where knockdown of SAPCD2 led to a peak accumulation of cells in the G1 phase and decrease accumulation in S phase in the RKO cell line but a decreased accumulation of cells in the G1 phase with an increase in S phase in the HCT116 cell line 17.