EDNRA and neoplasm: Multivariate Cox regression analysis identified, primary therapy outcome (HR=0.522, P = 0.018), age (HR=1.734, P = 0.017), tumor status (HR=3.642, P < 0.001), and EDNRA (HR=1.566, P = 0.049) as independent prognostic factors in OS (P < 0.05).