Among these risk factors, LncRNAPRR34-AS1 has been reported to aggravate the progression of hepatocellular carcinoma 27, GLIS3-AS1 is found to be correlated with the poor prognosis of intraductal papillary mucinous neoplasms 28, and LINC01224 is reported to modulate the malignant transformation in colorectal human cancer, gastric human cancer, ovarian human cancer, and hepatocellular carcinoma 29-32. The gene discussed is LINC01224; the disease is pancreatic intraductal papillary-mucinous neoplasm.