Our previous studies have found that L1 cell adhesion molecule (L1CAM), which was high-expressed in ESCC tissues, interacted with Integrin β1 and upregulated the expression of the cytoskeletal protein ezrin via activating integrin β1/MAPK/ERK/AP1 signaling, leading to the malignant phenotypes of ESCC cells 31. Here, L1CAM is linked to esophageal squamous cell carcinoma.