Further studies showed that knockdown of Integrin β1 or L1CAM alone could inhibit the phosphorylation of AKT in ESCC cells with or without cisplatin treatment, and in the cells with simultaneous knockdown of Integrin β1 and L1CAM, the inhibition effect was more significant (Figure 4E). The gene discussed is L1CAM; the disease is esophageal squamous cell carcinoma.