The expression of PAR3 protein and gene was significantly increased in pancreatic cancer cells overexpressing MiR-4723 and decreased in cells overexpressing CAV2 or Wnt7A; the Claudin-6 protein expression was increased in pancreatic cancer cells overexpressing MiR-4723 and decreased in cells overexpressing CAV2 or Wnt7A (Fig. 6C,7B). The gene discussed is CLDN6; the disease is pancreatic neoplasm.