The correlation between the expression trends of CAV2 and EGFR was significantly higher in pancreatic cancer and its paraneoplastic tissues, and the relationship between the two expressions indicated a positive correlation (Fig. 3A, P < 0.001), after which we noted that the intranuclear EGFR expression level was significantly upregulated in CAV2 overexpressing pancreatic cancer cells relative to that in the control group by immunofluorescence assay (Fig. 5A). Here, EGFR is linked to familial pancreatic carcinoma.