The literature report suggests that CAV2 regulates various cancer cells' growth and biological activities 3.Further studies have shown that overexpressed CAV2 mechanically promotes PDAC progression and metastasis by disrupting focal adhesion (CCND1, IGTA1 and ZYX) and extracellular matrix (PLOD2, CAST and ITGA1) genes 4.Meanwhile, BRD4 can bind to the CAV2 promoter region and up-regulate the expression of CAV2, thereby promoting PDAC5.CAV2 has also been shown to be a target of Mir-29a, and high CAV2 expression is responsible for poor prognosis6. This evidence concerns the gene CAV2 and cancer.