Abnormalities in genes such as MYCN, ALK, TERT, PHXO2B, and ATRX have come to be regarded as high-risk factor for NB; however, high-risk NB is characterized by heterogeneous genetics, and more than 25% of high-risk NB patients do not show the abovementioned genetic abnormalities 4, 5. The gene discussed is ALK; the disease is neuroblastoma.