The specifically highly expressed MYCN in NB provokes the elevated expression of a set of genes such as PHOX2B, ASCL1, GATA3, ISL-1, HAND2, and TBX2, referred to as the core regulatory circuit (CRC), which is closely associated with super enhancers and epigenetic abnormalities 12, 17. Here, TBX2 is linked to neuroblastoma.