Furthermore, MTM knockdown (Fig. 4B) could markedly increase miR-873 expression (Fig. 4C), and reduce pGL3-XAF1 3' UTR luciferase activity (Fig. 4D) and XAF1 expression (Fig. 4E and F) in glioma cells treated with WZY-321. The gene discussed is MT1DP; the disease is central nervous system cancer.