Our analysis results revealed that the expression of TRIP13 was upregulated in HCC and had a positive correlation with early recurrence (Figure 6A-D) 34, 35.To further investigate the upstream molecular mechanism that caused the up-regulation of TRIP13 in HCC, we analyzed the promoter of TRIP13 through JASPAR and ALGGEN-PROMO databases. Here, TRIP13 is linked to hepatocellular carcinoma.