Mutations on VCP have been linked to several forms of neurodegenerative disorders (Watts et al., 2004; Johnson et al., 2010; Meyer and Weihl, 2014; reviewed in Sun and Qiu, 2020) and endogenous VCP associates with protein inclusions in both Huntington’s disease and Lewy body dementia (Hirabayashi et al., 2001). This evidence concerns the gene VCP and Huntington disease.