In the WT context, knocking down CYP46A1 expression in the striatum, via an adeno-associated virus-mediated delivery of selective shCYP46A1, reproduced the HD phenotype, with spontaneous striatal neuron degeneration and motor deficits, as assessed by rotarod (Boussicault et al., 2016). Here, CYP46A1 is linked to Huntington disease.