Cultures of HD astrocytes, from different mouse models, show a downregulation of mRNA levels for cholesterol biosynthesis (HMGCR, CYP51, 7DHCR) and efflux (APOE, ABCA1) genes, associated with a decrease of APOE protein levels and secretion of APOE lipoprotein in the medium. Here, CYP51A1 is linked to Huntington disease.