Protein levels of the glutamate transporter GLAST are also decreased in the striatum and cortex of R6/2 mice (Estrada-Sánchez et al., 2009), associated with neuronal vulnerability, and the selective inhibition of both GLT1 and GLAST in R6/2 brain slice worsen electrophysiological properties of HD cortical neurons (Estrada-Sánchez et al., 2019). Here, SLC1A3 is linked to Huntington disease.