Pro-inflammatory mediator levels follow a brain specificity, with an up-regulation of IL-6, IL-8, TNFα, CCL2, IL-10, MMP9 in port-mortem HD human striatal tissue, but only IL-6, IL-8 and MMP9 in the cortex and cerebellum, CCL2 (Björkqvist et al., 2008; Silvestroni et al., 2009). This evidence concerns the gene TNF and Huntington disease.