There are other genes including sortilin related receptor (SORL1), complement receptor 1 (CR1), and bridging integrator 1 (BIN1) that have been implicated in increasing AD risk (Lambert et al., 2009; Carrasquillo et al., 2010; Seshadri et al., 2010; Tanzi, 2012). Here, CR1 is linked to Alzheimer disease.