Noradrenergic neurons of the locus coeruleus are some of the first neurons to form fibrillar tau (Braak and Del Tredici, 2012) and degenerate in AD (Iversen et al., 1983; Mann et al., 1984; Förstl et al., 1994; Matthews et al., 2002; Zarow et al., 2003; Liu et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.