Also, cholinergic neurons that degenerate in AD rely on retrograde transport of nerve growth factor (NGF) from hippocampus and cortex for proper function (Mufson et al., 2008; Schliebs and Arendt, 2011; Cattaneo and Calissano, 2012; Triaca and Calissano, 2016), and an imbalance in proNGF to mature NGF has repeatedly been implicated in AD (Cuello and Bruno, 2007; Cuello et al., 2007; Iulita and Cuello, 2014). The gene discussed is NGF; the disease is Alzheimer disease.