ACHE and Alzheimer disease: Post-mortem histology studies that found reductions in cholinergic markers in the brain and neurons in the nucleus basalis of Meynert laid the foundation for the “cholinergic hypothesis of AD” (Bowen et al., 1976; Davies and Maloney, 1976; Mesulam, 1976; Whitehouse et al., 1982; Mann et al., 1984) and were the motivation for acetylcholinesterase inhibitor drug treatments used in AD patients.