PICALM and Alzheimer disease: Approximately 20 single nucleotide polymorphisms (SNPs) in the non-coding region of PICALM have been associated with AD in several GWAS (Harold et al., 2009; Lambert et al., 2009; Carrasquillo et al., 2010; Corneveaux et al., 2010; Seshadri et al., 2010; Tanzi, 2012).