However, TDP-43 neuropathology was also identified in post-mortem AD brain (Amador-Ortiz et al., 2007; Uryu et al., 2008; Josephs et al., 2014, 2016), and is often observed in older adults with LATE (Nelson et al., 2019; Katsumata et al., 2020; Robinson et al., 2020; Uemura et al., 2022). This evidence concerns the gene TARDBP and Alzheimer disease.