SNCA and multiple system atrophy: Caspase-1 has also been shown to truncate α-synuclein at the C-terminal end in the proteolipid protein α-synuclein (PLP-SYN) transgenic mouse model of MSA, which promoted α-synuclein aggregation, motor deficits, and a reduction in tyrosine hydroxylase-positive neurons in the substantia nigra (Bassil et al., 2016).