For example, amyloid-beta peptides are implicated in Alzheimer’s disease, TAR DNA-binding protein 43 is implicated in amyotrophic lateral sclerosis and frontotemporal lobar degeneration, the huntingtin protein is implicated in Huntington’s disease, and α-synuclein is implicated in PD (Arrasate and Finkbeiner, 2012; Halliday et al., 2012; Stefanis, 2012; Blokhuis et al., 2013; Cheignon et al., 2018). The gene discussed is SNCA; the disease is Parkinson disease.