They also presented the same phenomenon confirming higher CYP1B1 expression in RCC cell lines compared to normal kidney tissue which was found to be linked with tumor grade and stage.54 In 2016, researchers from South Korea, explored the same phenomenon and studied the behavior of CYP1B1 in cells expressing higher level of CYP1B1, induced by either 7,12-dimethylbenz[a] anthracene (DMBA) or an overexpression vector. The gene discussed is CYP1B1; the disease is neoplasm.