CYP1B1 and energy intake: Whats more, Cyp1b1 deletion was found to be responsible for the alteration of the in vivo expression of 560 liver genes, such as suppression of PPARγ, stearoyl CoA desaturase 1 (Scd1) and many genes stimulated by PPARα, each consistent with this switch in energy storage mechanism.20 Another research group from this institute found that CYP1B1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development.