MYOC and juvenile open angle glaucoma: Normally, in eyes, MYOC mRNA is expressed in the iris, ciliary body, and trabecular meshwork,36 as well as in retinal photoreceptor cells37 and optic nerve head—specifically, the astrocytes.38 Perfusing the trabecular meshwork with mutant recombinant protein results in an increase in outflow resistance.39 Huang et al., investigated mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in a cohort of 67 unrelated Chinese Juvenile onset open-angle glaucoma (JOAG) patients.