It also metabolizes estrogen via 16-hydroxylation, resulting in formation of the potent mitogen 16 hydroxyestrogen.58 Now consistent with these information, Brett et al., (2010) investigated the role of CYP1B1 in the development and maintenance of angiotensin II – induced hypertension by infusing angiotensin II into rats for 13 days. This evidence concerns the gene CYP1B1 and Hypertension.