CYP1B1 and primary congenital glaucoma: It metabolizes substrates of endogenous origin including retinol metabolism to retinal, the hydroxylation of melatonin, dietary plant flavonoids, and the formation of genotoxic catechol estrogens.8,14 Stoilov et al.,15 identified CYP1B1 as the gene affected in primary congenital glaucoma and presented to be the first example in which mutations in a member of the cytochrome P450 super family results in a primary developmental defect.