However, they acknowledged that unfortunately so far there is no satisfactory explanation for the mechanism through which these compounds aid in cancer prevention.86 Last year, another research group compared the effects of a western diet, with or without oral benzo[a]pyrene (BaP) treatment, on the development of nonalcoholic fatty liver disease (NAFLD) in Cyp1a1(−/−) mice versus wild-type mice. The gene discussed is CYP1A1; the disease is metabolic dysfunction-associated steatotic liver disease.