In children, myelin oligodendrocyte glycoprotein (MOG)-associated disorders (MOGAD) represent another major class of autoimmune disorders where MOG, a minor component of the central nervous system myelin sheath, is the target antigen; pediatric MOGAD most frequently manifest with acute demyelinating syndromes such as acute disseminated encephalomyelitis or optic neuritis, but rarer manifestations, including cortical encephalitis, have been described (16). The gene discussed is MOG; the disease is autoimmune disease.