LGI1 and Autoimmunity: The most frequent and best characterized NSAS are anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (10–12), and autoimmunity with NSAbs targeting the leucine-rich, glioma-inactivated protein-1 (LGI1), and the contactin-associated protein-2 (CASPR2) (13–15).