MOG and Autoimmunity: In children, myelin oligodendrocyte glycoprotein (MOG)-associated disorders (MOGAD) represent another major class of autoimmune disorders where MOG, a minor component of the central nervous system myelin sheath, is the target antigen; pediatric MOGAD most frequently manifest with acute demyelinating syndromes such as acute disseminated encephalomyelitis or optic neuritis, but rarer manifestations, including cortical encephalitis, have been described (16).