The expression of NECTIN-4 in the muscle-invasive UC is reported to be 68.2% (20), compared with 8.7% of HER2 (14), and TROP-2 is known to be expressed in normal urothelium and in ≤83% of urothelial carcinoma (21). The gene discussed is TACSTD2; the disease is urothelial carcinoma.