ERBB2 and neoplasm: HER2 is a growth-promoting tyrosine kinase receptor, whose overexpression, though uncommonly, is highly associated with tumor progression and poor prognosis in UC (14, 15).RC48-ADC is a novel humanized anti-HER2 antibody conjugated with MMAE via a cleavable linker, impairing the formation of the microtubule network of target cells (16).