In chronic myeloid leukemia (CML), FBXW7 expression is integral to initiation, progression, and maintenance of leukemia stem cells (LSCs) associated with downregulation of c-MYC (215), and ablation of FBXW7 results in increased c-MYC and activated p53 pathway, further promoting LSC apoptosis (216). This evidence concerns the gene FBXW7 and chronic myelogenous leukemia, BCR-ABL1 positive.