FBXW7 dramatically suppresses glucose metabolism and reduces the 18F-FDG uptake of pancreatic cancer cells through regulating the expression of thioredoxin binding protein (TXNIP) in a c-MYC-dependent manner, whose regulatory mode can be summarized into the FBXW7/c-MYC/TXNIP axis (114). Here, TXNIP is linked to familial pancreatic carcinoma.