SKP1 and neoplasm: The S-phase kinase-associated protein 1 (SKP1)-cullin-1 (CUL1)-F-box-protein (SCF) complex belongs to the really interesting new gene (RING) family of E3 ubiquitin ligases, mediating the degradation of ~20% proteins related to cell-cycle regulation, transcription, oncogenesis, and tumor suppression (6).