FBXW7 and cancer: The FBXW7 gene (Gene ID: 55294) maps to chromosome region 4q31.3 including 18 exons, where mutations are frequently detected in multiple human cancers, such as colorectal cancer (CRC) (8, 9), ovarian cancer (10), breast cancer (BC) (11), endometrial cancer (12), and human T-cell acute lymphoblastic leukemia (T-ALL) (13).