By virtue of flow cytometry, apoptosis assays, and caspase 3/7 activity assays, researchers found that overexpression of FBXW7 accelerates GC tissue apoptosis through inducing the ubiquitination and degradation of RhoA (45), which is known to promote survival by triggering the expression of BCL2 gene (47). This evidence concerns the gene BCL2 and gastric cancer.