FBXW7 and gastric cancer: For example, miR-223 was detected upregulated in cisplatin-resistant GC cell lines, and the elevated expression of miR-223 inhibits cisplatin sensitivity of GC cells in vitro; these results can be explained by miR-223 target protein FBXW7, which regulates cell cycle and apoptosis presumably through ubiquitin-mediated proteolysis of MCL-1 (187).