FBXW7 and glioblastoma: FBXW7 facilitates apoptosis of glioblastoma cells through the ubiquitination and proteolysis of histone deacetylase 7 (HDAC7) (62), which localizes to the inner membrane of mitochondria and will be released into and sequestered within the cytoplasm in response to the initiation of apoptotic cascades (63).