Just as mentioned before, on the one hand, FBXW7 has been reported to dampen stemness properties of CSCs through the EMT and Wnt/β-catenin signaling pathways; on the other hand, the genetic silencing of FBXW7 confers accumulation of c-MYC, finally repressing the state of dormancy and sensitizing cancer cells to therapies, which has been substantiated in vitro and in vivo studies. The gene discussed is MYC; the disease is cancer.