MYC and oral cavity squamous cell carcinoma: Likewise, Tanshinone IIA (Tan IIA) suppresses HK-mediated glycolysis of oral squamous cell carcinoma (OSCC) cells by promoting FBXW7-mediated degradation of c-MYC and inhibiting the AKT-c-MYC signaling, exhibiting its natural antitumor activity (144).