In melanoma, loss of FBXW7 is relevant to enrichment of Notch1, enhanced expression of Notch1 target genes, as well as acceleration of angiogenesis, which vividly elucidates FBXW7 as a critical suppressor of angiogenesis partly through degrading its substrate Notch1 and influencing its downstream signaling (97). The gene discussed is NOTCH1; the disease is melanoma.