Additionally, cyclin E/CDK2 overactivation due to FBXW7 deficiency could induce hyper-phosphorylation of the centromere protein CENtromere Protein A (CENP-A) at the N-terminal Ser18 site, thus promoting chromosome missegregation and micronucleus formation, demonstrating that the FBXW7-dependent cyclin E is related with CIN via centromere dysfunction (165, 166). This evidence concerns the gene CCNE1 and cervical squamous intraepithelial neoplasia.