Another in vitro study generated adenocarcinomas exhibiting aneuploidy, which were derived from FBXW7-/-; p53-/- cell lines, implicating that ablation of FBXW7 and p53 synergistically promotes the occurrence of CIN and CRC tumorigenesis (172). This evidence concerns the gene FBXW7 and cervical squamous intraepithelial neoplasia.