ZEB1 and neoplasm: FBXW7 expression abundance is relevant to tumor clinicopathologic features, and FBXW7 is capable of dampening EMT process partly through downregulating EMT upstream transcription factors such as Snail 1 (45, 102) and zinc-finger E-box-binding homeobox 1 (ZEB1) (45), whereas the downregulation of FBXW7 expression reverses its inhibitory role.