In perihilar cholangiocarcinoma (pCCA), the high mobility group A1 (HMGA1) interacts with thyroid hormone receptor interactor 13 (TRIP13), and the HMGA1-TRIP13 axis promotes cell stemness by downregulating FBXW7 expression and thus stabilizing c-MYC, the latter in interplay with Wnt/β-catenin signaling (209). The gene discussed is HMGA1; the disease is hilar cholangiocarcinoma.