FBXW7 and hepatocellular carcinoma: In terms of targeting FBXW7 itself, the downregulation of prolyl isomerase Pin1 contributes to upregulation of FBXW7 and ensuing destruction of MCL-1, which potentiates the toxicity of sorafenib to prevent cell proliferation and induce apoptosis in hepatocellular carcinoma (HCC) (58).