The signatures of Ultraviolet (SBS7, P=0.081, Wilcoxon test), POLE (SBS10a/b, P=0.092, Wilcoxon test), MMRdeficiency (SBS15, P=0.550, Wilcoxon test), and BRCA (SBS3, P=0.630, Wilcoxon test) in the tumor are also more enriched but lack statistical significance. Here, POLE is linked to neoplasm.