FBN1 and adenoma: Our study revealed that the incidence of FBN1 methylation from control to CRC though adenoma or polyp can gradually produce powerful strength according to the quadratic equation Y = 0.108 + 0.479X − 0.08X2; the transcriptional inactivation associated with FBN1 methylation might start from normal colonic epithelium; the FBN1 methylation incidence related with the quadratic equation promoted the transcriptional inactivation to gradually accelerate the expansion and ultimately lead to the occurrence of CRC.