In the present work, our study aimed to find out both the variation regularities and mechanisms changing the characteristics of FBN1 methylation and the relationship between FBN1 methylation in tissue colorectal cell and that in cell-free DNA feces during CRC tumorigenesis and to investigate whether FBN1 methylation acted as an early biomarker in screening of early CRC. Here, FBN1 is linked to colorectal carcinoma.