Our study revealed that the incidence of FBN1 methylation from control to CRC though adenoma or polyp can gradually produce powerful strength according to the quadratic equation Y = 0.108 + 0.479X − 0.08X2; the transcriptional inactivation associated with FBN1 methylation might start from normal colonic epithelium; the FBN1 methylation incidence related with the quadratic equation promoted the transcriptional inactivation to gradually accelerate the expansion and ultimately lead to the occurrence of CRC. Here, FBN1 is linked to polyp.