FBN1 methylation of control samples was used as a standard reference; this study showed that ORs (95% CI) of FBN1 methylation in CRC and control tissues were 124.79 (62.86–248.35); those in feces were detected to be 30.87 (16.48–57.85). The gene discussed is FBN1; the disease is colorectal carcinoma.