Based on this quadratic curve equation, the metabolizing speed of the DNMT that can catalyze FBN1 methylation might begin slowly, then gradually increase during benign diseases (adenoma or polyp), and then rapidly develop during CRC; this process of DNMT synthesizes or degrades physiological activity and participates in the transformation or progression of human cancers by mediating the methylation of cancer suppressors. The gene discussed is DNMT1; the disease is cancer.