Differences in the proportions of each cell type in bilateral tumors with different genetic backgrounds [T1L (tumor from the left lobe in patient 1) vs. T1R (tumor from the right lobe in patient 1)] were more obvious than those in tumors with the same BRAF V600E mutation [T2L (tumor from the left lobe in patient 2) vs. T2R (tumor from the right lobe in patient 2) and T3L (tumor from the left lobe in patient 3) vs. T3R (tumor from the right lobe in patient 3)] (Figure 1G). This evidence concerns the gene BRAF and neoplasm.