Moreover, CSF1 induces pro-tumoral M2 macrophage polarization through binding to CSF1R (37), whereas CXCL9 and CXCL10 are involved in T-cell recruitment manifested as chronic lymphocytic thyroiditis (38), which has been associated with a better prognosis of PTC (39). This evidence concerns the gene CXCL9 and Hashimoto thyroiditis.