Mice treated with a combination of AHCC® and DICB had smaller tumor volumes compared to mice treated with a combination of water and DICB (Figure 1B) although the frequencies of tumor infiltrating hematopoietic cells (CD45+), CD4+ and CD8+ T cells were similar in mice treated with AHCC® and water in addition to DICB (Figure 1C). Here, CD8A is linked to neoplasm.