Similarly to tumor-infiltrating T cells, splenic CD8+ and CD4+ T cells in mice treated with the combination of AHCC® and DICB had increased expression of Ki-67 and CTLA-4 while granzyme B expression in splenic CD8+ and CD4+ T cells were barely detected by flow cytometry (Figures 2C, D). This evidence concerns the gene MKI67 and neoplasm.