VH3 gene family representation was higher in the ACPA+ RA/PD patient, and by individual variable region genes, IGHV4– 31, IGKV1-33 and IGLV1-47 were overrepresented, while IGHV4-4, IGHV4-38, IGHV1-69 and IGLV1-51 were underrepresented (Supplementary Figure 2). Here, PRTN3 is linked to rheumatoid arthritis.