In addition to IL-17A (57) and IL-17F (58), IL-17C (59, 60) and IL-17E (61, 62) can also aggravate psoriatic lesions; meanwhile, IL-17A and IL-17C can enhance atherosclerotic plaque instability, and IL-17E is protective against atherosclerosis (63, 64). The gene discussed is IL25; the disease is atherosclerosis.