PTGS2 and non-small cell lung carcinoma: Besides, the inflammatory enzyme cyclooxygenase-2 (COX-2) was found to overexpress in substantial malignancies (115) and its expression in NSCLC was related to angiogenesis (116, 117), metastasis (118, 119), and apoptosis resistance (120), the tumorigenic effects of which were partly regulated by the metabolite of COX-2, prostaglandin E2 (PGE2) that plentiful within the lung tumor microenvironment (TME).