SPRY4 and non-small cell lung carcinoma: (168) reported that epigenetic silencing of lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) occurs in NSCLC cells by direct transcriptional suppression regulated by the Polycomb group protein EZH2 and patients lacking expression of SPRY4-IT1 had poor overall survival, which means that SPRY4-IT1 can be recognized as a useful biomarker for NSCLC prognosis.