Moreover, Circular RNA hsa_circ_0008305 (circPTK2) and transcriptional intermediary factor 1 γ (TIF1γ) were verified considerably downregulated in NSCLC cells undergoing EMT and tumor metastasis induced by TGF-β, indicating circPTK2 as a prospective therapeutic target for advanced NSCLC (106). The gene discussed is TRIM33; the disease is non-small cell lung carcinoma.