(83) examined KDM6A, a member of the mixed-lineage-leukemia (MLL2) H3K4 methyltransferase complex, that catalyzes H3K27me2/3 with its JumonjiC (JmjC) domain (84, 85) and found that expression of KDM6A protein was higher in NSCLC tissues than that in the corresponding paracancer tissues while high KDM6A expression was positively related to the poor prognosis of patients. This evidence concerns the gene KDM6A and non-small cell lung carcinoma.