MBD2 and non-small cell lung carcinoma: (78) used the TCGA and cBioportal databases to evaluate the expression profile of methyltransferases and demethylases in NSCLC and found that higher expression of H3K4 histone demethylases (KDM1A, KDM5A, KDM5B and KDM5D) was associated with poor overall survival while patients with low expression of H3K4 histone methyltransferases SMYD3 also suffered from worse prognosis.