These responsive T cells positively correlate with PD-L1+PD-L2+ DCs, PDL1+ CCR2+, or MMP9+ macrophages or MHC I/II+ cancer cells, mainly through costimulatory CD28-CD80, ICOS-ICOSLG, coinhibitory PDCD1-CD274/PDCD1LG2, HAVCR2-LGALS9, and CLTA4-CD80/CD86. The gene discussed is CD274; the disease is cancer.