Other risk factors have related to recurrence of APS manifestation such as the presence of LAC or triple aPL positivity (i.e., the concomitant presence of anti-cardiolipin (aCL) and anti-β2‐glycoprotein I (aβ2GPI) and lupus anticoagulants (LAC) (8, 12). The gene discussed is LCT; the disease is autoimmune polyendocrinopathy.