CD40LG and metabolic syndrome: Arterial thrombosis during follow-up was also more common in patients with very high titer (>4-fold upper normal limit) aPLs of the IgM isotype (both anti-B2-GPI and anti-cardiolipin) hypertension, dyslipidemia, heart valve disease, higher aGAPSS, and higher mortality in comparison to patients with no recurrence during follow-up (Table 2).