We identified 4 patterns of thrombotic recurrence, namely, “arterial”, “venous”, “combined”, and “breakthrough”, each associated with different risk factors that can be easily evaluated in any APS clinic explicitly APS-presenting symptom, patients’ age, aPL isotypes, and comorbidities (e.g., non-criteria manifestation, hypertension, and others). Here, FASLG is linked to autoimmune polyendocrinopathy.