CD40LG and autoimmune polyendocrinopathy: Interestingly, when comparing aPLs among patients with the arterial pattern of recurrence to our entire cohort of primary APS patients (including those with other patterns of re-thrombosis), the link with aPLs of the IgM isotype remained persistent regardless of titers (B2GPI IgM 64.5% vs. 43.6%, p = 0.002, aCL IgM 56.5% vs. 39% p = 0.001).