NR4A1 and neoplasm: Their investigations revealed augmented antitumor immunity in mice in which both Nr4a1 and Nr4a2 were deleted specifically in Treg cells (Foxp3CreNr4a1fl/flNr4a2fl/fl mice; referred to as “Foxp3CreNr4a-DcKO mice”), suggesting that the suppressive activity of tumor Treg cells was attenuated upon loss of Nr4a1 and Nr4a2.