Huang et al. (123) used inflammatory macrophage activation models to demonstrate that the inflammation activation-associated corepressor (GPS2 and SMRT)-eRNA-CCL2 regulatory axis, in addition to finding that LNA-targeted Ccl2 enhancer E-transcribed eRNA in white adipose tissue macrophages of obese (ob/ob) mice, can partially reverse meta inflammation and insulin resistance. Here, GPS2 is linked to Insulin resistance.