BRD4 and Sepsis: Estradiol cypionate (ET) inhibitors, such as JQ1 and I-BET762, can recognize acetylated histones by interfering with the BET family proteins BRD2, BRD3, BRD4 and BRDT (178). Thus, targeting this protein class can promote LPS-induced inflammatory gene expression in macrophages and significantly improve survival, as observed in an in vivo sepsis model (178, 179).