Studies have reported significant differences in eRNA expression levels among multiple chemokine gene-related enhancer regions (including CXCL1-3, CXCL5-6 and CXCL8), which are all up-regulated in IBD, Crohn’s disease (CD), ulcerative colitis (UC) and controls using CAGE and qPCR (143). This evidence concerns the gene CXCL8 and inflammatory bowel disease.