Lysine-specific demethylase 1 (LSD1) was identified as a selective mediator of H3K4 demethylation, with LSD1 inhibitors affecting the progression of acute myeloid leukaemia by disrupting the enhancer with the SNAG structural domain transcriptional repressor GFI1 (200). This evidence concerns the gene GFI1 and acute myeloid leukemia.