Subsequently, Tan et al. (102) identified the second functional eRNA (XLOC_005968) in T-ALL cells, namely ARIEL, which recruits intermediary proteins to the ARID5B enhancer, promotes enhancer-promoter interaction and activates ARID5B expression, and thereby positively regulating TAL1-induced transcription and MYC oncogene expression, to accelerate T cells malignant progression. Here, TAL1 is linked to acute lymphoblastic leukemia.