Shi et al. (98) found that monocyte ADAMDEC1 over-expression in patients with SLE was induced by the stimulation of pro-inflammatory cytokines, moreover, under LPS stimulation, the binding of the p300-NFκB complex to enhancer 2 generates eRNA157 that promotes p300 activation, leading to an increase in H3K27ac at the enhancer and promoter region, thus, affecting the regulation of ADAMDEC1 mRNA and SLE-related inflammatory gene expression. Here, EP300 is linked to systemic lupus erythematosus.