As shown in Figure 4B, multiple complement-related proteins, including complement C1q subcomponent subunit C (C1QC), complement subcomponent C1r (C1R), complement C4-A (C4A), and complement C4-B (C4B) were downregulated in SLE, especially in LAs and HAs. The gene discussed is C1QC; the disease is systemic lupus erythematosus.