By having a view on IL-2, we noted reduced IL-2 mRNA expression in the tumoral region compared to the control region (Figure 2D), indicating that low levels of IL-2 and the presence of other immunosuppressive cytokines like TGF-beta and IL-10 in the tumor microenvironment may contribute to augmented Treg numbers in NSCLC (31, 35). Here, IL2 is linked to non-small cell lung carcinoma.