We found a significant upregulation of IL-21 production in the supernatants of aCD3/aCD28 antibodies cultured total lung cells from the TU region of patients with NSCLC as compared to the CTR region (Figure 1I). This finding indicates higher T cell infiltration as the possible cause for the increased IL-9 levels found in the tumoral area of the lung of NSCLC patients (30). The gene discussed is IL21; the disease is non-small cell lung carcinoma.