These translocations are found in approximately 3-7% of TAL1/LYL1+ T-ALL cases, however, there are frequent alterations at the TAL1 locus in T-ALL including deletions such as TAL1d, which arises from a site-specific DNA recombination event causing a 90kb deletion upstream of TAL1 (62). Here, LYL1 is linked to acute lymphoblastic leukemia.