NOTCH1 was identified as an oncogene in T-ALL by its involvement in a t(7;9)(q34;q34.3) translocation that placed the 3’ end of the NOTCH1 gene under control of the TCRB locus, resulting in constitutive activation of NOTCH1 in T cell progenitors (100). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.