SPP1 and metabolic dysfunction-associated steatohepatitis: A cross-sectional survey of 19 NASH patients reported that plasma SPP1 levels in NASH patients were higher than those in HC patients, whereas plasma and hepatic SPP1 levels in patients with advanced fibrosis were higher than those in patients with no or mild fibrosis, indicating that the histological characteristics of disease severity in NASH patients are associated with SPP1 (23).