SIRT1 and non-small cell lung carcinoma: Western blot also demonstrated that SIRT1 depletion remarkably reduced the ratio of LC3-II/LC3-I and increased the protein level of p62 in H1299/CDDP cells (Fig. 4G), suggesting the inhibitory effect of si-STAT1 on cell autophagy in CDDP-resistant NSCLC cells.