ESR1 and endometriosis: A meta-analysis with more than 17,000 patients and 191,000 controls identified 5 novel SNPs associated with steroid signalling pathways as well as 5 secondary association signals, including two at the ESR1 locus, resulting in 19 independent SNPs which the authors postulated might contribute to 5.19% of variance in endometriosis (Sapkota et al. 2017).